Biotin and derivatives
Medchemexpress LLC DBCO-NHS ester 2 250mg | 1384870-47-6 | 250 MG
DBCO-NHS ester 2 is a dibenzocyclooctyne-derived N-hydroxysuccinimide (NHS) ester used as an amine-reactive linker for copper-free click chemistry and antibody-drug conjugate synthesis. The activated NHS ester enables rapid conjugation to primary amines, while the DBCO moiety enables strain-promoted azide-alkyne cycloaddition (SPAAC) without copper catalysts.
- Amine-reactive NHS ester for efficient amide bond formation
- Enables strain-promoted azide-alkyne cycloaddition (SPAAC) for copper-free click chemistry
- High purity (99.69%) suitable for bioconjugation applications
- Molecular weight 430.45 Da; formula C25H22N2O5
- Powder form; store at -20°C for long-term stability
- Packaged as a 250 mg solid for laboratory use
Medchemexpress LLC L-biotin | 21788-37-4 | 99.7% | 244.31 g/mol | C10H16N2O3S | 50 MG
L-biotin is the unnatural enantiomer of biotin supplied as a high-purity research reagent for laboratory use (not for human or clinical applications).
- High purity (reported 99.5-99.7%).
- Cas number 21788-37-4.
- Molecular weight 244.31 g/mol.
- Chemical formula C10H16N2O3S.
- Available in small milligram quantities such as 50 MG.
Medchemexpress LLC Fp-biotin | 259270-28-5 | MFCD02094222 | 99.8% | 592.75 g/mol | C27H50FN4O5PS | 5 MG
FP-Biotin is a biotin-labeled organophosphorus activity-based probe for detecting and quantifying serine hydrolase enzymes in biochemical and proteomic assays. Supplied as a solid or as a 10 mM solution in DMSO, it enables enrichment of biotinylated peptides by avidin/streptavidin capture for downstream analysis of FAAH, ABHD6, and MAG-lipase activity.
- High purity (99.8%) suitable for analytical applications.
- Biotin tag enables efficient avidin/streptavidin-based enrichment.
- Detects and quantifies serine hydrolase activity such as FAAH, ABHD6, MAG-lipase.
- Available as solid and ready-to-use DMSO solution formats.
- Compatible with plasma and proteomic workflows for biomarker discovery.
![Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 g/mol | C18H23N3O5S2 | 1G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238902.png-250.jpg)
Medchemexpress LLC Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate | 158913-22-5 | MFCD00083163 | 98.1% | 425.52 g/mol | C18H23N3O5S2 | 1G
Succinimidyl 6-[3-(2-pyridyldithio)propionamido]hexanoate is an alkyl/ether-based PROTAC linker containing an N-hydroxysuccinimide (NHS) ester for amine coupling and a pyridyldisulfide moiety for thiol-directed conjugation. It is used in PROTAC and bioconjugation synthesis and features a reducible disulfide that enables controlled cleavage in downstream applications.
- Provides an NHS ester for efficient conjugation to primary amines.
- Contains a pyridyldisulfide cleavable disulfide for thiol chemistry.
- Suitable as a linker in PROTAC and bioconjugation synthesis.
- Molecular formula C18H23N3O5S2; molecular weight 425.52 g/mol.
- Soluble in DMSO at approximately 50 mg/mL; may require sonication.
- Store powder at -20°C for long-term stability; solvent solutions require low-temperature storage.
- High purity (98.1%) suitable for research applications.
Medchemexpress LLC DBCO-biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 | C28H30N4O3S | 50MG
DBCO-Biotin is an alkyl chain-based PROTAC linker and click-chemistry reagent that contains a dibenzocyclooctyne (DBCO) moiety conjugated to biotin, enabling copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Supplied as a white to off-white solid, it is used for biotinylation, conjugation, and PROTAC synthesis in chemical biology applications.
- High purity of 98.5%.
- Molecular weight 502.63 g/mol.
- Molecular formula C28H30N4O3S.
- Soluble in DMSO at 31.25 mg/mL (62.17 mM).
- Store protected from light under inert gas; solid recommended at -20°C.
- Packaged as 50 mg vial.
- Enables copper-free click conjugation via SPAAC.
Sigma Aldrich Fine Chemicals Biosciences Biotin European Pharmacopoeia (EP) Reference Standard | 58-85-5 | MFCD00005541 |
Biotin European Pharmacopoeia (EP) Reference Standard | Mol Wt: 244.31 | 58-85-5 | MFCD00005541 |
Sigma Aldrich Fine Chemicals Biosciences Biotin meets USP testing specifications | 58-85-5 | MFCD00005541 | 5G
Biotin meets USP testing specifications | Purity: 97.5-102.0% | Mol Wt: 244.31 | 58-85-5 | MFCD00005541 | 5G
Medchemexpress LLC Sulfo-NHS-biotin sodium | 194041-65-1 | MFCD00078535 | ≥90.0% | C14H18N3NaO8S2 | 10MG
Sulfo-NHS-Biotin sodium is a water-soluble, amine-reactive biotinylation reagent that covalently labels primary amines on proteins and other biomolecules. The sulfonated N-hydroxysuccinimide ester increases aqueous solubility, allowing efficient labeling in physiological buffers and streamlined downstream analysis for detection and affinity workflows.
- Water-soluble amine-reactive reagent for labeling primary amines.
- Enables efficient labeling in aqueous buffers without organic solvents.
- Supports detection, pull-downs, and affinity purification workflows.
- High solubility in water and DMSO for flexible formulation.
- Stable when stored sealed and protected from moisture; follow datasheet handling.
- Available as a solid or as a pre-made DMSO solution for convenience.
Medchemexpress LLC Diazo biotin-PEG3-azide | 1339202-33-3 | MFCD28334530 | 95.5% | C33H45N9O7S | 10MG
Diazo biotin-PEG3-azide is a multifunctional PEG3 linker combining a cleavable diazo functional group, a biotin affinity tag, and an azide reactive handle. It is designed for efficient biotinylation and capture of alkyne-bearing biomolecules using click chemistry and for use as a linker in chemical biology workflows.
- Provides azide functionality for CuAAC and SPAAC click reactions.
- Includes a biotin tag for affinity purification and detection.
- Contains a diazo group enabling photo-cleavage or crosslinking.
- PEG3 spacer improves solubility and reduces steric hindrance.
- Suitable for biotinylation, pull-down assays, and linker synthesis.
Medchemexpress LLC NHS-MMAF | 1404073-19-3 | 97.2% | C49H78N6O12 | 10MG
NHS-MMAF is an N-hydroxysuccinimide-activated derivative of monomethyl auristatin F used as a payload intermediate for antibody-drug conjugate (ADC) synthesis. It acts as a tubulin polymerization inhibitor and is intended for research use in ADC linker and conjugation development; it is described in patent WO2012143499 (intermediate 219).
- NHS-activated ester for amine conjugation.
- Suitable for antibody-drug conjugate linker chemistry.
- High reported purity (97.2%).
- Solid, white to off-white appearance for easy handling.
- Soluble in DMSO for reaction setup.
- Serves as a payload precursor for cytotoxic conjugates.